Fri Jul 11 2025

42 articles - From Friday Jul 04 2025 to Friday Jul 11 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Am J Clin Nutr

Evaluation of dietary protein and amino acid requirements: a systematic review.

Our systematic review of human indispensable amino acid and protein requirement research from January 2000 to May 2024 finds limited studies across the lifecycle, particularly in pregnancy, lactation, infancy, childhood, and adolescence.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Biological responses during high-dose protein nutrition in the critically ill: a randomized controlled trial.

Larger increases in WBPB were observed in critically ill patients receiving a high-dose protein supplementation strategy, and these increases were associated with a biological program reflecting neutrophil-mediated bacterial killing. Clinical trial registration

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Call to Action: A Need for Community-Driven Minimum Information Standards for Food Composition Data.

Additionally, we outline existing organizations, standards, and tools relevant to the development of a new standard. Finally, we detail expected activities for the working group, as well as anticipated challenges to developing and deploying a globally acceptable food composition data reporting standard.

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Diet optimization: modeling iron and zinc absorption by nonlinear programming and piecewise linear approximation using NHANES.

This study provides practical examples for researchers who seek to improve the accuracy of their diet models through the implementation of nonheme iron and zinc absorption equations using either NLP or PLA.

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Effectiveness of a digital weight management program on diet quality: A randomized controlled trial.

A CP was significantly more effective than SNG for improving diet quality and weight loss among a diverse sample of adults living with overweight or obesity in the U.S. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE WHERE IT WAS OBTAINED

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Effects of consuming an iron supplement with a meal containing animal or plant-based meat on indicators of iron status and anemia in women of reproductive age with iron deficiency: a randomized, controlled study.

Findings suggest that the "meat factor" does not contribute substantially to improvements in iron status in women of reproductive age with iron deficiency when consumed with an iron supplement for 8 weeks. Clinical trial registry

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Effects of quintuply-fortified salt on the micronutrient status of females of reproductive age in Punjab, India: a randomized, community-based trial.

Methods We conducted a double-blind, randomized, controlled, community-based trial. A total of 998 NPFRA were randomly assigned to receive: 1) QFS with iron as encapsulated ferrous fumarate, zinc, vitamin B and folate, among NPFRA at high risk of deficiency.

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Empirical Dietary Index for Lower Urate Levels and Risk of Gout: Evidence From Cohort Studies.

A replicated empirical index predicting lower plasma urate is associated with significantly lower risks of gout and related cardiometabolic conditions. Consuming such a diet with lower uricemic potentials could be a novel, promising approach to preventing gout.

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Fried food consumption-related gut microbiota is associated with obesity, fat distribution and cardiometabolic diseases: results from two large longitudinal cohorts with sibling comparison analyses.

Fried food consumption-related microbiome is associated with a higher risk of obesity, central fat distribution, and cardiometabolic diseases, emphasizing the importance of dietary choices in the management and prevention of chronic diseases.

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Infant Vitamin B12 Status and its Predictors - Cross-Sectional Baseline Results from an Ongoing Randomized Controlled Trial.

A substantial proportion of Norwegian infants have biochemical signs of low vitamin B12 status, regardless of the cut-off. Lower status was observed in partially and exclusively breastfed infants, compared to non-breastfed infants. However, it is unclear whether these biomarker patterns have clinical significance. Further research is needed to determine consequences of low vitamin B12 biomarker concentrations in early infancy.

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Metabolic plasticity of the gut microbiome in response to diets differing in glycemic load in a randomized, crossover, controlled feeding study.

In healthy humans, diet impacts microbial metabolism and enzymatic activity but not the overall diversity of the gut microbiome. This emphasizes the relevance of dietary components in activating expression of specific bacterial genes and their impact on host metabolism.

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Patterns of perinatal exposure to PUFAs and child neurodevelopment: evidence from Mendelian randomization using FADS cluster variants.

These findings supported the potential beneficial effects of perinatal exposure to LC-PUFAs on child neurodevelopment while highlighting possible adverse effects associated with exposure to LA and DGLA.

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The global leadership initiative on malnutrition (GLIM).

The use of GLIM malnutrition criteria that closely resemble those found in other validated tools raises the opportunity to further standardize malnutrition language and severity cutoffs used to characterize malnutrition criteria. Clinical Trial Registry number - Not applicable.

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Inflamm Bowel Dis

Construct Validity of the Toronto IBD Global Endoscopic Reporting Score Compared to Inflammatory Biomarkers After 12-Month Follow-Up.

The TIGER score is a simple endoscopic score that can be used for both CD and UC that has been shown to have both construct validity with inflammatory marker and noninferiority to the current best-referenced endoscopic scores over a 12-month follow-up period. Future studies should begin incorporating TIGER as a measure of clinical response to interventions and therapeutics.

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Culturally Informed Digital Behavioral Intervention Development for Inflammatory Bowel Disease: A Qualitative Study.

Racial and ethnic background influences IBD patients' illness perception, coping, and desires for support. Findings can directly inform the design and content of digital behavioral interventions in IBD towards increased applicability and equitable engagement.

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Feasibility and Safety of Small Bowel Capsule Endoscopy in Very Early-Onset Inflammatory Bowel Disease: A Multi-Institutional Study.

Small bowel capsule endoscopy for very early-onset inflammatory bowel disease is feasible with diagnostic utility, and it can be performed safely with appropriate evaluation using patency capsules.

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Novel Autologous Regulatory T-Cell Therapy Ameliorates DSS-Induced Colitis in Humanized Mice.

Autologous Treg therapy ameliorated the symptoms of DSS-induced colitis in a humanized mouse model. The autologous PBMC-humanized DSS-induced colitis model may serve as a robust preclinical platform for evaluating the efficacy of personalized Treg cell therapy for IBD.

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J Crohns Colitis

MR Cell Size Imaging Revealing Intestinal Fibrosis to Predict Intestinal Disease Progression in Patients with Crohn's Disease.

TD-dMRI-derived d serves as a noninvasively microstructural biomarker for intestinal fibrosis in CD, which significantly enhances the accuracy in predicting disease progression risk.

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Recombinant Herpes Zoster Vaccine Lowers Shingles Complication Risk in Patients with Inflammatory Bowel Disease.

RZV substantially lowers the risk of HZ complications in patients with IBD, offering significant clinical benefits to those at high risk due to immunosuppression. These findings underscore the importance of RZV as part of preventive care strategies in patients with IBD.

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The Risk of Mild, Moderate, and Severe Infections in IBD patients - A prospective, multicentre observational cohort study (PRIQ).

Mild and moderate infections are common among IBD patients and are particularly associated with both patient characteristics and specific immunosuppressive treatments. These findings emphasize the need for vigilant monitoring, especially for patients at higher infection risk, and allow for more personalized advice on benefit-risk of IBD treatments.

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Liver Transpl

Building bridges: The power of near-peer mentorship in hepatology.

We also provide a case study of our experience with a dedicated group of near-peer mentors in hepatology. By sharing our perspective on near-peer mentorship we hope to expand the uptake and support of lateral mentorship programs within our field.

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Comparing outcomes of deceased-donor and living-donor liver transplants in patients with portal vein thrombosis.

LDLT can achieve outcomes comparable to DDLT in patients with PVT. PVT should not be considered a contraindication for LDLT in selected patients at experienced centers.

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Hepatic artery dissection after living-donor liver transplantation requires different management based on the locations and clinical outcomes: A retrospective cohort study.

In conclusion, although HAD presents with severe imaging findings, it generally has a favorable prognosis. However, when HAD involves only PHA, owing to the high risk of HAT, more frequent surveillance and aggressive management are recommended.

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Potential strategies in porcine liver xenotransplantation: A bridge to allotransplantation and beyond.

Additionally, we propose that brain-dead human subjects (decedents) be used to validate the efficacy of porcine livers in supporting split or marginal human liver grafts. These developments are expected to lay the groundwork for clinical trials aimed at improving the outcomes of patients with end-stage liver disease, potentially expanding the pool of transplantable organs and providing new therapeutic options for these patients.

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Preoperative von Willebrand factor is an independent predictive biomarker for posthepatectomy liver failure - a multivariable model with APRI+ALBI.

The combination of vWF-Ag with APRI+ALBI demonstrates a favorable predictive potential for PHLF risk assessment. We provide two pathways for clinical assessment 1) a cut-off-based system and 2) a more complex multivariable model that can be calculated in a specifically designed smartphone application.

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Prognostic communication, Psychological distress, and caregiving burden among caregivers of patients with decompensated cirrhosis.

Quality of prognostic communication was not significantly associated with caregiving burden or depression symptoms. These findings emphasize the substantial psychological distress and burden experienced by caregivers of patients with DC and highlight prognostic understanding as a potential modifiable target for improving their psychological outcomes.

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Selective splenectomy centered on graft-to-spleen volume ratio is a practical option in living donor liver transplantation to prevent early allograft dysfunction: A Prospective validation study.

Selective SPX centered on GSVR is a feasible and practical option in LDLT to screen out high-risk recipients and improve their graft function for EAD prevention.

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Pancreas

Long-term Outcomes of Splanchnic Venous Thrombosis in Acute Pancreatitis.

Most patients with SVT following AP demonstrate spontaneous recanalization. A key predictor for non recanalization is the severity of pancreatitis.

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Pancreatology

Critical appraisal of postpancreatectomy hemorrhage after pancreatoduodenectomy: an analysis of risk factors, treatment and outcomes in 860 consecutive cases.

The optimal approach to treatment of PPH takes into account location, timing and severity of the bleeding as well as the type of pancreatoenteric anastomosis. Appropriate treatment strategies for both early and late PPH include angiography, endoscopy, reoperation and conservative management or a combination of them.

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Prediction of metastatic potential of heterogeneous pancreatic ductal adenocarcinoma through gradient-based algorithms.

This work introduces a novel multiscale hybrid framework that is original both in its formulation integrating agent-based, continuum, and immune dynamics and in its application, where simulated biological signatures are used to train gradient boosting models for accurate prediction of metastatic potential.

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Prognostic impact of post-neoadjuvant CA19-9 values in pancreatic cancer: more pronounced following neoadjuvant chemotherapy compared to neoadjuvant chemoradiotherapy.

The prognostic significance of post-NACRT CA19-9 values is suboptimal compared to post-NAC CA19-9 values.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Clarification and standardization of dual-energy X-ray absorptiometry terminology for accurate scientific communication and clinical diagnostic accuracy.

These recommendations will enhance the clarity of SM-related measures (e. g., ALST, ALM), improve diagnostic accuracy, and facilitate meaningful comparisons across studies.

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Confronting the fatty acid problem in preterm infants: biological needs, nutritional gaps.

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Neglected micronutrients - considering a broader set of vitamins and minerals in public health nutrition programs worldwide: A narrative review.

We conclude that more information, based on dietary assessments, nutritional biomarker surveys, and systematic surveillance of associated health conditions, is needed. Appropriate intervention programs, including changes in food systems to provide wider access to nutrient-rich foods, food fortification and targeted supplementation, should be implemented in settings where these deficiencies are confirmed.

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Providing multiple micronutrients through household salt.

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Should the recommendations for dietary protein and amino acid intake in humans be revised?

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Inflamm Bowel Dis

Response to "The Association of Inflammatory Bowel Disease and Eosinophilic Esophagitis: True Link or Surveillance Artifact?

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J Crohns Colitis

Creeping fat in Crohn's disease: an immunometabolic imbalance worth targeting?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

J Crohns Colitis

Adequacy of disclosures in oral presentations at the 20th Congress of European Crohn's and Colitis Organisation.

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Liver Transpl

CON: A multi-vendor organ procurement and transplantation network (OPTN) will not improve liver procurement and use.

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PRO: A multi-vendor organ procurement and transplantation network (OPTN) will improve liver procurement and use.

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Seeing Through the Machine: Ultrasound Assessment of Hepatic Artery Integrity During Normothermic Machine Perfusion.

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Letters&Replies

Letters to the editors and authors’ replies